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Contraindications and cautions include asthma (glutathione may trigger bronchospasm in sensitive individuals), platinum-based chemotherapy (glutathione may reduce drug efficacy), and certain genetic variations affecting cysteine and sulfur metabolism

To further support the impact of CBS on replenishing GSH levels under cystine-restricted conditions, we expressed a codon-optimized CBS (CBS OPT ), which is resistant to the designed sgRNA (Fig

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Administration of cruciferous-derived compounds, such as sulforaphane, may increase Glutathione and Glutathione-related enzymes