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The results showed that Exendin-4 also promoted bone marrow-derived macrophage polarization to M2 phenotye and TGF-1 secretion via PKA-STAT3 signaling (31)

The effect of DPP-4 inhibitors, GLP-1 receptor agonists and SGLT-2 inhibitors on cardiorenal outcomes: a network meta-analysis of 23 CVOTs

It is important to note that escalation schedules varied between trial cohorts