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Funding This study was supported by the Delegation for Clinical Research of the University Medical Center of Nantes (CHU de Nantes)

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In adults, glucuronidation and sulfation play a major role in APAP metabolism, and approximately 5% of the substrate is converted into NAPQI (Court et al., 2001

You may notice symptoms only once those stores are substantially depleted

This suggested DSIP might modulate pain processing through mechanisms distinct from classical opioid pathways

Patients with PD should be evaluated for associated systemic health risks to ensure comprehensive management