Semaglutide (Wegovy) is more widely covered for weight loss than tirzepatide (Zepbound) because its been approved longer
In the past, it was recognized that it was produced by intestinal L cell, but now it is found that pancreatic cell can also secrete GLP-1
GIP was historically underestimated, but it turns out to be important for energy balance and fat tissue regulation
Physiologically, glucagon raises blood sugar, but in this specific pharmacological context, activating the GCGR increases thermogenesis (energy expenditure)
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Finally, lifestyle factors (diet, activity level) influence outcomes alongside the medication