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10.3810/pgm.2010.05.2138 62 FriedrichC.PortA.RingA.Graefe-ModyU.GiessmannT.IovinoM.et al (2011)

Abstract OBJECTIVE This analysis of 3,375 adults with overweight/obesity across the Semaglutide Treatment Effect in People with obesity (STEP) 1, 3, and 4 trials evaluated whether more participants with prediabetes had normoglycemia after 68 weeks treatment with once-weekly semaglutide 2.4 mg plus lifestyle intervention versus placebo and assessed changes in glucose metabolism in participants with prediabetes

The drugs appear to not only reduce appetite but fundamentally alter food preferences, potentially disrupting what food historians call the industrial palate learned preferences for artificial flavors and preservatives

Swelling, bruising, and temporary soreness are anticipated

The historical track record look, you can look at other major disruptions historically