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Semaglutide works by stimulating a receptor that increases insulin production, lowers glucagon levels (a hormone that raises blood sugar), and slows down how quickly the stomach empties

Several recently determined non-peptidic ligand bound GLP-1R structures 13,14,16 have uncovered previously unknown binding pockets that may have implications in their pharmacological profiles such as biased signaling and allosteric agonism (Supplementary Fig