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Despite these promising results, MK-0493 did not show clinically significant efficacy in obese human participants at either a 400 mg PO dose or a step-titrated 800 mg PO dose ( ad libitum energy intake model, MK-0493 was associated with a small and marginally significant reduction in total 24-hour energy intake, whereas 30 mg of sibutramine (positive control) was associated with a significant reduction in total 24-hour energy intake ( While MK-0493 did not achieve clinical success, an analysis of these studies can provide potential rationale for failure

Additionally, an SLC25A40 variant is associated with hyperlipidemia 35

Nutritional and supplementation strategies to preserve lean mass during GLP-1 receptor agonist therapy (review). Obesity Pillars , 2025

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Patients with risk factors such as obesity, extended diabetes duration, or specific medication use might need extra monitoring

Some people develop a temporary egg aversion during weeks 5 through 8