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Linarine markedly suppressed the release of inflammatory cytokines, including IL-1 and TNF-, in HCECs, along with regulated the levels of the purinergic receptor [77]
The results demonstrated a significant reduction in this ratio upon HC and CCCP administration, indicating mitochondrial depolarization (Figures 7B,C)
Zinc Zinc is present at high levels in the brain where it has catalytic, structural, and regulatory roles in cellular metabolism (see the article on Zinc)
Functional indicators of oxidative stress included relative levels of 3-chlorotyrosine (3-CT), an established biomarker of a chronic inflammatory response, and aconitase activity, a biomarker of mitochondrial superoxide production
Lin et al., 2017
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