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Because they rely on the standard digestive process, it can take much longer to reach a "steady state" in the blood

Because many of these compounds affect insulin secretion or glucose uptake, combining them with pharmaceuticals can raise the risk of hypoglycemia

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This means that protease inhibition acts to protect the API during it passage across the enterocyte, but concerns about long-term interference with digestive process in the gut are absent, because of the transient nature of the inhibitory activity deployed