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Research published in the Annals of the New York Academy of Sciences by Goldstein et al

The significance of these compounds in the treatment of ovarian cancer, ovarian ischemia, polycystic ovary syndrome, age-related reproductive insufficiency, or menopausal syndrome has been suggested

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Case in point: a 2013 review supported growth hormone therapy as a treatment for patients with cognitive impairment, theorizing that growth hormone may interact with receptors in the central nervous system associated with learning and memory.20 Another case in point: a 2018 review found that IGF-1 plays a major role in adult brain function and decreases with age, a decrease that seems to precede cognitive decline in the elderly.21 To tie this all together, we can point to a 2012 clinical trial directly examining the effects of tesamorelin on cognitive function