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Safety Comparison# Key Differences Summary# Receptor targets : Bioglutide activates 4 receptors (GLP-1/GIP/glucagon/IGF-1)

Interestingly, a separate drug currently in late-stage development, MariTide (maridebart cafraglutide), is built on the opposite premise: blocking the GIP receptor rather than activating it

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Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion

References Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L et al (2018) Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome