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81 , e0004016 (2017)

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doi: 10.1029/2020JE006394 17 Cabestrero.Sanz-MonteroM

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Another recent example of a class I c-MET inhibitor in earlier phases of clinical development is AMG - 337 (Amgen, Thousand Oaks, California, USA), an orally bioavailable highly selective inhibitor of the c-MET receptor with a half maximal inhibitory concentration (IC50) of 1 nM which has reached phase II studies in patients with GI cancer or other MET-amplified solid tumors [112]