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Benzyl alcohol has been associated with serious adverse events and death in pediatric populations, particularly neonates, due to: Immature metabolic pathways for benzyl alcohol detoxification Accumulation of benzyl alcohol and its metabolite (benzoic acid) Gasping Syndrome characterized by metabolic acidosis, gasping respirations, CNS depression, and cardiovascular collapse For neonatal research applications, use only preservative-free Sterile Water for Injection

Based on these researches, clinical trials targeting HO-1 should be carried out to evaluate its application in the treatment of DN, so as to provide evidence for clinical application

Glucagon-like peptide 1 therapy: from discovery to type 2 diabetes and beyond

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