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To test the hypothesis that increasing mitochondrial NAD + in a cell-type specific manner could improve regeneration, we used adeno-associated virus (AAV) expressing human SLC25A51 under the control of the hepatocyte-specific Serpina7 promoter

The liver stores significant amounts of B12, providing a reserve that can last several months to years, depending on the individual's metabolic needs and the severity of prior deficiency

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Study-related adverse events Adverse reactions reported in 5% of patients and occurring more frequently with Victoza compared with placebo included nausea (21.4% vs 4.4%), vomiting (12.1% vs 2.2%), diarrhea (7.1% vs 2.9%), constipation (5.7% vs 1.5%), increased lipase (15.0% vs 8.8%), GFR decreased (6.4% vs 5.1%), and headache (5.0% vs 2.9%)