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Glutathione peroxidase 3 serum levels and GPX3 gene polymorphisms in subjects with metabolic syndrome

In the published Phase 2 research (Jastreboff et al., NEJM 2023), Retatrutide produced the largest body-weight outcomes of any single-compound incretin programme reported to date, distinguishing the triple-agonist class from dual agonists like Tirzepatide and single-target agonists like Semaglutide

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Both drugs can blunt appetite, leading to decreased caloric consumption

Other DPP4 inhibitors were not included in this meta-analysis

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