how do glp-1 cause weight loss Does Semaglutide Work to Lose Weight? GLP-1 Agonists For Obesity In

504,505,506 GLP-1 enhances the insulin signaling pathway in the liver by activating the GLP-1R, especially through the phosphorylation of insulin receptor substrates and the activation of the PI3K/Akt signaling pathway, thereby increasing hepatic insulin sensitivity, facilitating glucose uptake and utilization, and reducing hepatic gluconeogenesis

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Clinical trial data suggests tirzepatide produces greater average weight loss than semaglutide, largely because it activates both the GLP-1 and GIP receptors rather than just GLP-1

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Seino Y, Rasmussen MF, Zdravkovic M, et al

-Qu cuestiones hay que tener en cuenta en el seguimiento farmacoteraputico de pacientes que estn en tratamiento con estos medicamentos