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Together, they create a synergistic effect: better fat metabolism, improved energy, and healthier liver function

While there are limited treatment options for liver fibrosis, a recent clinical trial showed in the explorative secondary endpoint that tirzepatide (TZP), a glucagon-like peptide-1 receptor (GLP1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) dual agonist that was approved for the treatment of type 2 diabetes in 2022 28 , reduces liver fibrosis in patients with metabolic dysfunction-associated steatohepatitis (MASH) 29

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Clinical relevance in humans remains uncertain, but semaglutide training for physicians requires discussing this risk during informed consent