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In the obesity trials, participants on the 12 mg dose reached up to roughly 2829% mean body-weight reduction at 68 to 80 weeks, with a large share crossing the 25% and 30% thresholds, the strongest weight result reported for a GLP-1-class compound in a phase 3 trial [5]

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While some individuals notice subtle appetite changes within 24 to 48 hours, many feel no significant difference initially

An important advantage of this therapy is that it does not significantly increase hormones such as cortisol or prolactin, which are often associated with unwanted side effects

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