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Upon exam, his right calf region is swollen, cyanotic and tender with noticeable petechiae, and he experiences calf pain on dorsiflexion of the foot with the knee straight

The mechanism involves decreased expression of mitofusin 2 (Mfn2), leading to increased mitochondrial fission and reactive oxygen species (ROS) production, ultimately resulting in cardiomyocyte apoptosis [118]

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Front Neurosci 14:599646 Meloni A, DeYoung M, Lowe C, Parkes D (2013) GLP-1 receptor activated insulin secretion from pancreatic -cells: mechanism and glucose dependence

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