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In an exploratory analysis of the results of the REWIND trial, a CVOT for dulaglutide (another once-weekly GLP-1RA), a highly significant reduction of 13%-14% was observed in the risk of substantive cognitive impairment, also after adjustment for baseline scores, age ,sex, ethnic origin or education [26]
The Myth of the Magic Shot Its tempting to believe a weekly injection is all you need to reach your goals
Additionally, the positive outcomes of ongoing trials SURPASS-CVOT and SURMOUNT-MMO will provide definitive evidence regarding the cardiovascular safety and efficacy of tirzepatide compared to dulaglutide and reduction in morbiditiy and mortality in adults with obesity respectively
The receptor target is the same, yet the presentation, regulatory pathway, and availability differ
This educational protocol presents a once-daily subcutaneous evening approach using a practical dilution for clear insulin-syringe measurements