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[8] Metformin with GLP-RA & Long-term Outcomes: In patients with T2D, dual therapy with metformin and GLP-RA has demonstrated a 39% lower incidence of adiposity-related cancers (HR 0.61) and a 67% reduction in all-cause mortality (HR 0.33) compared to DPP-4 inhibitor use, with effects most pronounced in younger people with obesity

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These additional calories should come primarily from protein and carbohydrates, not fat

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In exercise research it is frequently paired with carbohydrate, because insulin appears to help drive carnitine into muscle Volek's and later LCLT studies co-administered carbohydrate with the dose

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