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These mutations are in strong linkage disequilibrium, creating a two-allele risk haplotype and hence increasing the overall risk of this disease [14]

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They can be aggravated by certain medications, such as NSAIDs

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However, some studies have reported that rosiglitazone and pioglitazone, both TZD drugs, could be associated with an increased risk of prostate and pancreatic cancer [107]

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