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Combination therapy has shown somewhat higher rates of GI events compared to either monotherapy, and slow, gradual dose titration significantly improves tolerability

The compound's primary target, NNMT, sits at a critical metabolic intersection where NAD+ precursor availability meets cellular methylation capacity

Sometimes patients require more than three sessions

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Thus, caution is advised when considering EGCG supplements for diabetic patients, particularly at high doses

Bridges, P