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Reactions were terminated by washing with ice-cold Krebs buffer

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Epigenetic regulation plays a pivotal role in the pathogenesis of DKD, providing a molecular basis for the phenomenon of metabolic memorywhereby transient episodes of hyperglycemia induce long-lasting pathological changes in renal cells (64, 65)

OSA evaluation was available in 69 participants, of whom 71.4% were finally diagnosed (59.1% experienced mild, 34.6% moderate, and 6.1% severe OSA)

BBB integrity was improved, and more tumor cells underwent immunogenic cell death (ICD), releasing danger signals that further activate immunity

VD mitigates mitochondrial ROS via astrocytic glutathione (GSH) up-regulation and -glutamyl transpeptidase (GGT) activation [7], while VE preferentially quenches lipid peroxidation chains, potentiating endogenous antioxidants (SOD and catalase) in preclinical models [53]