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Key safety risks include hypoglycaemia when combined with insulin or sulphonylureas, gastrointestinal interactions, pancreatitis, gallbladder disease, and dehydration-related acute kidney injury

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Glutathione peroxidase 4 (GPX4) is a well-known enzyme that protects against ferroptosis, as it uses glutathione (GSH) to reduce lipid peroxides to fatty alcohols and thereby terminates lipid peroxidation chain reactions