Glipizide and Glibenclemide can reduce insulin requirements by 5-15%
In recent years, off-label use for weight loss has contributed to GLP-1 RAs shortages, limiting access for patients with diabetes
Studies have shown that L-Carnitine supplementation enhances fat oxidation and energy efficiency during exercise, allowing your muscles to perform better and recover faster
Carlat Verdict: To prevent metabolic side effects when beginning an antipsychotic, start with metformin, but consider a GLP-1 RA for patients who have already been on antipsychotics for a while with a BMI 30 kg/m 2 (or 27 kg/m 2 and obesity-related health problems)
3. Supports Cardiovascular Health
The onset and recurrence of depression have been linked to diverse metabolic factors, including hyperglycemia, dyslipidemia, and insulin resistance