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Catalase (CAT) is a high-turnover, peroxisomal heme enzyme that decomposes H 2 O 2 generated during fatty-acid oxidation and downstream of SOD [102, 106]

Funding This research was funded by the National Natural Science Foundation of China (31872809) and the Natural Science Foundation of Shandong Province, China (ZR2020QC065)

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10 M menadione, a concentration which has been shown to upregulate GPX3 transcription in an immortalized bronchial epithelial cell line 60 , consistently induced expression of both GPX3 and NQO1 in phLF while the effects in phBEC were more variable