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It does not identify obesity or metabolic disease

Type 2 diabetes mellitus A meta-analysis of 13 randomized, controlled feeding trials that substituted plant-derived PUFA (primarily linoleic acid [LA]) for saturated fatty acids or carbohydrates for 3 to 16 weeks in generally healthy adults showed a decrease in fasting insulin concentration and insulin resistance but no effect on fasting glucose concentration (123)

Biochem J (1980) 191:4217

Table II provides a summary of studies that have previously applied such types of TYR inhibitors