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Activating gene expression in mammalian cells with promoter-targeted duplex RNAs

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Specifically, Ubx N51A -RNA association was strongly detected on exons differentially spliced upon Ubx WT /Ubx N51A co-expression ( Pura , pAbp) , with moderate association on Rgk1 and absence on Chas (Figure 1K-L, Figure S2P-Q)

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Is this amount of GH sustainable in the short-term without encountering health debilitating side effects