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It also modifies the immunosuppressive TME, promoting immune activation, suggesting that enhancing chimeric antigen receptor cell function may represent a potential strategy for glioblastoma therapy (71)

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Briefly, PSCs were harvested on day 4

SIRT1, localized in the nucleus, deacetylases and activates proliferator-activated receptor gamma coactivator-1 (PGC-1), which leads to increased mitochondrial biogenesis 103

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