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Sodiumglucose cotransporter 2 inhibitors (SGLT2is) have shown kidney-protective effects in large kidney-dedicated outcome trials [4,5,6], and dedicated kidney outcome trials on glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1ras) are awaited

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Administration of placebo tablets concomitantly with oral semaglutide can reduce exposure to semaglutide by 35% in healthy subjects [28] and reinforces the dosing conditions to avoid administering other oral medications within 30 minutes of oral semaglutide [1, 28]