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GLP-1 receptors are located in the brain, and GLP-1 is created in the brain in preproglucagon neurons

The GLP-1 messages your pancreas to make insulin, which pulls glucose from your blood and your blood sugar is lowered to healthy levels

Weight loss is but one small side effect of these medications

The full effect builds over 36 months as doses are gradually increased

Obviously, people need to work with their doctor on what the starting dose needs to be

For example, certain FTO variants are associated with higher baseline appetite signaling, while specific GLP1R variants may correlate with differences in satiety response