While insulin resistance per se which allows glucose levels in the blood to rise to dangerous levels hasnt been found in chronic fatigue syndrome (ME/CFS), an exercise-related insulin resistance which was ameliorated by metformin did show up in cultured muscle cells from ME/CFS patients
In studies with mouse models of NAFLD and acute kidney injury (AKI), treatment with ACMSD inhibitors increased the transcription of mitochondrial and -oxidation genes, as well as restoring NAD + levels in the kidney and liver 235
American Journal of Psychiatry, 178, 437-446
If we go beyond fat metabolism, carnitine supports mitochondrial function as well as exercise recovery
The Foundation: Diet and Nutrition Semaglutide works best when paired with a healthy diet
Melanotan-2 is the better peptide if you want fast results and don't mind (or actively want) the sexual and appetite side effects