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Ann Intern Med 104:427429 Kuffner EK, Dart RC, Bogdan GM, Hill RE, Casper E, Darton L (2001) Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial

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Furthermore, GSTP1 exon 5 polymorphism is associated with lung cancer susceptibility

If a med goes through your liver, its taxing it, so you need a liver-loving nutrient like NAC or glutathione. Cohen lists the following classes of medications that are known to deplete Glutathione2: Acid blockers Analgesics Antacids Antibiotics Antivirals Tricyclic antidepressants Excess Body Fat Excess body fat triggers overproduction of several damaging proteins known to cause oxidative stress