3,4 GLP-1RAs mimic the action of endogenous GLP-1, activating GLP-1R, thereby enhancing insulin secretion, inhibiting glucagon release, delaying gastric emptying, and reducing food intake through central appetite suppression
The N-terminal region of GLP-1 is considered critical for receptor activation, whereas the C-terminal region predominantly facilitates receptor binding
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Ultra-processed foods tend to be low in fiber and micronutrients, making them less helpful when total intake is reduced