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The combination of the amylin analogue pramlintide and the recombinant human leptin metreleptin caused significant weight reductions ( - 11.5kg) in comparison with monotherapy in a 24-week phase 2 clinical trial [248]

When people discontinue these medications, they tend to regain the weight they lost

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For researchers focused primarily on metabolic markers, the 4mg to 8mg range appears to provide strong metabolic benefit with a favorable side effect profile