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The IGF-1R targeting of miR-515-5p was disrupted by A to G nucleotides substitution in the miR-515-5p binding sites of IGF-1R 3UTR, suggesting that the IGF-1R level in BC can be regulated by miR-515-5p binding on the polymorphic site in IGF-1R 3UTR

Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid

273 Using the lipid overload oxidative stress-related calcification model, it was found that the downregulation of p53 expression suppressed GPX4 and SLC7A11 expression and decreased the GSH/GSSG ratio, thereby promoting lipid peroxidation and ferroptosis

pylori upregulates HIF-1 expression via post-transcriptional regulation, which directly targets the LONP1 promoter to enhance its expression, ultimately leading to cellular overgrowth

Chessa MA, Iorizzo M, Richert B et al (2020) Pathogenesis, clinical signs and treatment recommendations in brittle nails: a review