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Despite the absence of efficacy on clinical endpoints, the trials reported biomarker changes consistent with semaglutides hypothesised biological effects

Despite these promising outcomes, notable gaps remain in the research

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By then the lesion can be of quite a considerable size and since they occur in heavily sun-exposed sites, definitive treatment can be a toss-up between curative therapy with severe cosmetic defects or a less aggressive approach taking into account the likelihood of invasive disease occurring and the patients co-morbidities and age