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This extrarenal production allows tissues to generate active vitamin D independently of systemic hormone levels, explaining why adequate 25(OH)D concentrations are necessary even when circulating 1,25(OH)2D levels appear normal

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Both receptors display a differential expression in normal tissues

Dysbiosis amplifies barrier dysfunction and immune activation, while inflammation further perturbs microbial composition and impairs epithelial repair, establishing a self-sustaining pathological cycle

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