DXA before and during therapy in higher-risk patients (older adults, lower baseline BMI, prior weight cycling, baseline frailty markers) provides the mass data, but the function data is what tells you whether the mass changes matter
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Some patients experience shifts in dopamine and serotonin signaling, which can dampen motivation and increase perceived effort during daily activities
Therefore, men on important oral meds (like certain diabetes drugs, blood thinners, etc.) should separate their dosing from PT-141 by a couple of hours and monitor those medications effectiveness
doi: 10.1007/s13300-012-0015-6 55