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Current research is therefore primarily focused on the preparation of new OA dosage forms (nanoparticles, liposomes, solid dispersions, phospholipid complexes), or the development of its new (semi)synthetic derivatives with better pharmacological properties in terms of potency, toxicity, bioavailability, and solubility [272, 273, 275, 277]

IGF-1 DES has drastically reduced affinity for these IGF binding proteins, with approximately 90% less binding to IGFBP-3 (the primary carrier protein)

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