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Kari et al., 2011

Pugliese, D., Sabba, C., Ettorre, G., Berardi, E., Antonica, G., Godi, L., Palasciano, G., Lee, S

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Many such reactions require functioning mitochondria

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The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo