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Discussion and Future Directions 7.1

Contact your GP if you experience: Persistent fatigue, weakness, or shortness of breath (possible anaemia) Numbness, tingling, or balance problems (possible B12 deficiency) Muscle cramps, spasms, or irregular heartbeat (possible magnesium or potassium deficiency) Bone pain or frequent fractures (possible vitamin D or calcium deficiency) Poor wound healing or frequent infections (possible zinc or vitamin C deficiency) Seek urgent medical attention (call 111 or 999 as appropriate) for severe palpitations, chest pain, fainting, or signs of severe allergic reaction

Table S3 The risk of bias for included trials

New England Journal of Medicine, 384(11), pp.9891002

revealed that -carotene supplementation remarkably diminished plasma lipid peroxide levels in patients [146]

This is the other half of the muscle-protection pair, and the evidence behind it is consistent