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A 2015 meta-analysis found that NAC reduced chronic bronchitis or COPD exacerbations, though later research has been mixed, including a 2024 trial in mild-to-moderate COPD that did not find a significant reduction in overall exacerbation rates with high-dose NAC.1 22 Fertility Oxidative stress can damage sperm, eggs, and the reproductive environment, which is one reason antioxidants are often studied in fertility research

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