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GHK is not thought to bind each gene individually

However, higher doses can reduce the effects caused by oxidative stress and inflammation in COPD, demonstrating a positive impact on the rate of exacerbation [117]

Meanwhile, Luciferase activity assays revealed no significant difference in GGCT promoter activity between Gln+ and Gln- groups, indicating that Gln does not directly regulate GGCT transcription (Fig

However, more research is needed to fully understand this aspect

"A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S -transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase" (PDF)

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