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The most commonly known incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), formerly called Gastric inhibitory peptide ( In view of this, a widespread search of SCOPUS, PubMed, and CENTRAL was performed using the following string (obesity or insulin resistance) AND (tirzepatide or Dual GIP and GLP-1 Receptor Agonist)

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We then organized these pathways into enriched terms within functional clusters and conducted GSEA analysis ( Figure 2C