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(b) oxidative stress including increased activity of pro-oxidative enzymes including myeloperoxidase (MPO) and oxidative damage as indicated by elevated production of malondialdehyde (MDA), protein carbonyls (PCs) and advanced protein oxidation products (AOPP)

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Metformin significantly inhibited OCR by 47% ( Figure 6A ) and ECAR by 36% ( Figure 6B ) in rectal adenocarcinoma biopsies, when compared to baseline, demonstrating metformin-induced modulation of energy metabolism in rectal tumours from patients