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A cyclic AMP responsive luciferase construct introduced into Chinese hamster ovary (CHO) cells, allows a sensitive luminescent assay for thyroid stimulating antibodies with the capability of high throughput suitable for use in general laboratories (228)

Drug Design, Development and Therapy

So this isnt a full regulatory evaluation

Abbreviations ALP: alkaline phosphatase ALT: alanine aminotransferase AST: aspartate aminotransferase CKD: chronic kidney disease GGT: gamma glutamyl transpeptidase HGF: hepatocyte growth factor HPP: hypophosphatasia NSHA: nonspherocytic hemolytic anemia PLP: pyridoxal 5-phosphate TNSALP: tissue-nonspecific alkaline phosphatase Declarations Acknowledgement The support of the Herman Lopata Chair in Hepatitis Research is gratefully acknowledged

doi: 10.1056/NEJMoa1607141