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Users in a moderate deficit (300-500 calories/day) consistently report better outcomes than those eating at maintenance

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Sachdev et al (2003) used a single-chain antibody directed against IGF-1R (IGF-1R scFv-Fc) to examine the effects on IGF-1R signalling

PUFAs are esterified into PE via the ACSL4/LPCAT3 axis, forming peroxidation-susceptible PE-PUFA substrates (e.g., PE-AA/AdA)

They share common GI side effects, such as nausea, diarrhea, and vomiting