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In sum, while mechanistic plausibility is strong and extrapolation from prostate oncology supports the concept of therapeuticwindow expansion, there is presently no highlevel randomized evidence in cervical/gynecologic oncology showing hydrogels expand the therapeutic window (i.e., allowing higher tumor dose or less toxicity at equivalent tumor dose)

These results support further evaluation in chronic dosing paradigms, inclusion of both sexes, and pharmacokineticpharmacodynamic studies to optimize translation

elegans Notch proteins, LIN-12 and GLP-1, are functionally redundant for certain cell-cell interactions during embryogenesis [15]

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Double staining of TGF-2 and p-c-MET allowed the classification of the tumor specimens into four groups (Fig

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